Sandbox:MGS

Waldenström's macroglobulinemia Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mirdula Sharma, MBBS [2]

Electrophoresis and Immunofixation

Serum protein electrophoresis

• Screening test for monoclonal protein
• The key diagnostic criterion for Waldenström's macroglobulinemia is the detection of monoclonal IgM protein.
• Sharp, narrow spike or dense band of monoclonal IgM

Serum immunofixation

• Confirmatory test for presence of monoclonal proteins and to determine it's subtype.
• The quantitative IgM levels observed should be 2 or 3g/dL more than that found in the serum protein electrophoretic spike.

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