Ovarian germ cell tumor medical therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Monalisa Dmello, M.B,B.S., M.D. [2]

Stage I ovarian germ cell tumors

• Standard treatment options:
• Dysgerminomas
• Unilateral salpingo-oophorectomy with or without lymphangiography or computed tomography (CT)
• Unilateral salpingo-oophorectomy followed by observation
• Unilateral salpingo-oophorectomy with adjuvant radiation therapy or chemotherapy
• Other germ cell tumors
• Unilateral salpingo-oophorectomy with adjuvant chemotherapy
• Unilateral salpingo-oophorectomy followed by observation

Stage II ovarian germ cell tumors

• Standard treatment options:
• Dysgerminomas
• Total abdominal hysterectomy and bilateral salpingo-oophorectomy with adjuvant radiation therapy or chemotherapy
• Unilateral salpingo-oophorectomy with adjuvant chemotherapy
• Other germ cell tumors
• Unilateral salpingo-oophorectomy with adjuvant chemotherapy
• Second-look laparotomy

Stage III ovarian germ cell tumors

• Standard treatment options:
• Dysgerminomas
• Total abdominal hysterectomy and bilateral salpingo-oophorectomy
• Unilateral salpingo-oophorectomy with adjuvant chemotherapy
• Other germ cell tumors
• Total abdominal hysterectomy and bilateral salpingo-oophorectomy with adjuvant chemotherapy, with or without neoadjuvant chemotherapy
• Unilateral salpingo-oophorectomy with adjuvant chemotherapy, with or without neoadjuvant chemotherapy
• Second-look laparotomy

Stage IV ovarian germ cell tumors

• Standard treatment options:
• Dysgerminomas
• Total abdominal hysterectomy and bilateral salpingo-oophorectomy with adjuvant chemotherapy
• Unilateral salpingo-oophorectomy with adjuvant chemotherapy
• Other germ cell tumors
• Total abdominal hysterectomy and bilateral salpingo-oophorectomy with adjuvant chemotherapy with or without neoadjuvant chemotherapy
• Unilateral salpingo-oophorectomy with adjuvant chemotherapy with or without neoadjuvant chemotherapy