Waldenström's macroglobulinemia causes
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The most common causes of Waldenström's macroglobulinemia is somatic mutation in MYD88 (90% of patients) and a somatic mutation in CXCR4 (27% of patients).[1]
Less common causes of Waldenström's macroglobulinemia include:
- Chromosomal abnormalities: deletions of 6q23 and 13q14, and gains of 3q13-q28, 6p and 18q
- Environmental factors including exposure to farming, pesticides, wood dust, and organic solvents
- Chronic immune stimuation and autoimmune disorders[2]
References
- ↑ Waldenström's macroglobulinemia. Wikipedia (2015). https://en.wikipedia.org/wiki/Waldenström%27s_macroglobulinemia#cite_note-19 Accessed on November 6, 2015
- ↑ Epidemiology, pathogenesis, clinical manifestations and diagnosis of Waldenström macroglobulinemia. UpToDate (2015). http://www.uptodate.com/contents/epidemiology-pathogenesis-clinical-manifestations-and-diagnosis-of-waldenstrom-macroglobulinemia#H3 Accessed on November 6, 2015