Essential thrombocytosis history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]
Overview
People with essential thrombocytosis are usually asymptomatic. Symptoms[1] of ET may arise from vascular occlusion by thrombi or bleeding and may include vision disturbances, transient loss of consciousness, chest pain, intense burning pain in hands or feet(erythromelalgia), numbness and tingling of hands and feet, priapism (persistent and painful erection of the penis). Neurologic symptoms like headache may occur but the pathophysiology is not completely understood.[1] Rarely a family history may be present in patients with familial essential thrombocytosis.
History and symptoms
- People with essential thrombocytosis are usually asymptomatic. Patients may have symptoms of minimal bleeding that can go unnoticed until diagnosis. Most of the symptoms are vascular, either from thrombi occluding small and large blood vessels, though any blood vessel may be involved. Symptoms depend on the blood vessel that is involved.
- Symptoms of vascular occlusion:
- Symptoms from bleeding can occur despite the increased platelet count accounting to the dysfunctional platelets. Common sites of bleeding include eyes, nose (epistaxis), gums, gastrointestinal tract, skin (bruises). The bleeding itself is usually minimal.
- Neurologic symptoms like headache may occur but the pathophysiology is not completely understood.[1]
References
- ↑ 1.0 1.1 1.2 Brière JB (2007). "Essential thrombocythemia". Orphanet J Rare Dis. 2: 3. doi:10.1186/1750-1172-2-3. PMC 1781427. PMID 17210076.
- ↑ Koudstaal PJ, Koudstaal A (1997). "Neurologic and visual symptoms in essential thrombocythemia: efficacy of low-dose aspirin". Semin Thromb Hemost. 23 (4): 365–70. doi:10.1055/s-2007-996110. PMID 9263353.