Waldenström's macroglobulinemia must be differentiated from other B cell lymphoid neoplasms including:

Chronic lymphocytic leukemia/small lymphocytic lymphoma:

Always express CD5, usually CD23 positive^[1]

B-cell prolymphocytic leukemia:

Express bright surface IgM, CD20 and other B-cell antigens (CD19, CD22, CD79a, FMC7)^[1]

Follicular lymphoma:

Express CD10, HLA-DR, pan B-cell antigens (CD19, CD20, CD79a), CD21, and surface IgM, IgG, or IgA^[1]
Bone marrow infiltration of small, cleaved cells that are usually paratrabecular^[2]
Rearrangement of Bcl-2

Multiple myeloma:

Express CD138, CD38, CD79a, and VS38c and CD56(70%)^[1]
Presence of Plasmacytic cell infiltration of bone marrow, osteolytic lesions and renal insufficiency^[2]
Translocation involving chromosome 11 (t 11;14)

Mantle cell lymphoma:

Express CD5+ and CD23-, surface IgM and IgD and cyclin D1 in majority of cases^[1]
Infiltration of bone marrow by monomorphous, small lymphoid cells with irregular nuclei^[2]

Marginal zone lymphoma:

Expresses B cell markers CD19, CD20, and CD22^[1]
Infiltrates the bone marrow with a characteristic intertrabecular and intrasinusoidal pattern^[2]
Most common cytogenetic abnormalities are loss of 7q (19%) along with +3q (19%) and +5q (10% )

References=

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↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Clinical manifestations, pathologic features, and diagnosis of lymphoplasmacytic lymphoma. UpToDate (2015)http://www.uptodate.com/contents/clinical-manifestations-pathologic-features-and-diagnosis-of-lymphoplasmacytic-lymphoma?source=see_link&sectionName=PATHOGENESIS&anchor=H198194648#H198194648 Accessed on November 9, 2015
↑ ^2.0 ^2.1 ^2.2 ^2.3 Sahin I, Leblebjian H, Treon SP, Ghobrial IM (2014). "Waldenström macroglobulinemia: from biology to treatment". Expert Rev Hematol. 7 (1): 157–68. doi:10.1586/17474086.2014.871494. PMID 24405328.

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[UTD-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Clinical manifestations, pathologic features, and diagnosis of lymphoplasmacytic lymphoma. UpToDate (2015)http://www.uptodate.com/contents/clinical-manifestations-pathologic-features-and-diagnosis-of-lymphoplasmacytic-lymphoma?source=see_link&sectionName=PATHOGENESIS&anchor=H198194648#H198194648 Accessed on November 9, 2015

[pubM-2] 2.0 ^2.1 ^2.2 ^2.3 Sahin I, Leblebjian H, Treon SP, Ghobrial IM (2014). "Waldenström macroglobulinemia: from biology to treatment". Expert Rev Hematol. 7 (1): 157–68. doi:10.1586/17474086.2014.871494. PMID 24405328.

[1]

[2]

Waldenström's macroglobulinemia differential diagnosis

References=

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