Intracerebral metastases natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Complications

Common complications of intracerebral metastases include:

• Brain herniation
• Hemorrhage
• Coma
• Stroke
• Side effects of radiotherapy
• Side effects of chemotherapy

Prognosis

• Depending on the type of primary cancer, the age of the patient, the absence or presence of extracranial metastases, and the number of metastatic sites in the brain at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor.
• The median survival time of all patients with intracerebral metastases is 2.3 months.
• However, in some patients such as those with , the prognosis is much better with the median survival rate of up to 13.5 months.
• Favorable prognostic factors (median survival rate of 13.5 months) for intracerebral metastases include:

• No extracranial metastases
• Age less than 65 years
• Single site of metastasis in the brain

References

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