Linitis plastica laboratory tests
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]
Overview
Laboratory findings consistent with the diagnosis of linitis plastica may include abnormal complete blood picture, electrolyte abnormalities, occult bloodin stool, abnormal increase in the levels of ALT (alanine aminotransferase), lactate dehydrogenase (LDH), aspartate transaminase (AST) and positive tumor markers like the CA-125, CEA and beta hCG.[1]
Laboratory findings
Laboratory testing may be similar to that of any other type of gastric cancer and may include the following:[2]
- Complete blood count (CBC)
- To look for anemia (reduced hemoglobin)
- Complete metabolic panel (CMP)
- To look for any electrolyte abnormalities
- Stool testing for occult blood
- Serum chemistry tests
- Increase in ALT (alanine aminotransferase), lactate dehydrogenase (LDH), aspartate transaminase (AST) levels may be noticed
- Tumor markers testing may include CA-125, CEA and beta hCG
- Esophagogastroduodenoscopy with multiple deep biopsies
- Mucosa may look innocent or show superficial ulcerations as in gastritis.
- Histopathologic specimens show poorly differentiated, atypical signet ring cells diffusely infiltrating the stomach wall, submucosal fibrosis and thickening.[3][4]
- Upper gastrointestinal endoscopic ultrasound
- A very useful test that helps both in the diagnosis and to know the depth of the tumor invasion.
- A 10-20mm thickening of the submucosal layer is usually present.
- Chest x-ray
- To rule out metastasis
- CT and MRI of chest, abdomen and pelvis
- To know the local invasion and distant metastasis (included as part of staging the disease)
References
- ↑ Stomach cancer. Canadian cancer society. http://www.cancer.ca/en/cancer-information/cancer-type/stomach/diagnosis/?region=nb Accessed on December 9, 2015
- ↑ Stomach cancer. Canadian cancer society. http://www.cancer.ca/en/cancer-information/cancer-type/stomach/diagnosis/?region=nb Accessed on December 9, 2015
- ↑ Schauer, M; Peiper, M; Theisen, J; Knoefel, W (2011). "Prognostic factors in patients with diffuse type gastric cancer (linitis plastica) after operative treatment". European Journal of Medical Research. 16 (1): 29. doi:10.1186/2047-783X-16-1-29. ISSN 2047-783X.
- ↑ Stomach cancer. Wikipedia. https://en.wikipedia.org/wiki/Stomach_cancer Accessed on November 19, 2015.