Osteoma pathophysiology
|
Osteoma Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Osteoma pathophysiology On the Web |
|
American Roentgen Ray Society Images of Osteoma pathophysiology |
|
Risk calculators and risk factors for Osteoma pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]
Overview
Osteoma is a slow growing benign tumor of bone, occurring most commonly in the craniofacial skeletal structures, mainly in the nasal and paranasal (75-90%) cavities.[1] Osteoma arises from bone overgrowth, which is normally composed of connective tissue. Osteomas are slow growing tumors composed of compact or mature trabecular bone limited to craniofacial bones. The most common gene affected in multiple osteoma is the APC gene.
Pathogenesis
Osteoma arises from bone overgrowth, which is normally composed of connective tissue. Osteomas are slow growing tumors composed of compact or mature trabecular bone limited to craniofacial bones. These tumors occur mainly in the nasal and paranasal (75-90%) cavities.
Genetics
The hallmark of multiple osteomas is a mutation in the APC gene, that results in the Gardner syndrome.
Associated Conditions
Gross Pathology
On gross pathology, osteomas have a spongy to densely appearance, conformed of a blastic juxtacortical mass.
Microscopic Pathology
On microscopic histopathological analysis, slow-growing, bone-forming tumor can be shown with the presence of dense, compact mature bone in paucicellular fibrous stroma. Large trabeculae of mature, lamellar bone can be also be seen.
Gallery
References
- ↑ Abdel Tawab HM, Kumar V R, Tabook SM (2015). "Osteoma presenting as a painless solitary mastoid swelling". Case Rep Otolaryngol. 2015: 590783. doi:10.1155/2015/590783. PMC 4341844. PMID 25767729. Vancouver style error: name (help)