Proteus infection pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pathophysiology
Colonization
- Proteus is part of the normal human GI tract. Following self-contamination, Proteus accesses the urinary tract through the urethra and uses flagella to ascend in a retrograde manner to the upper urinary tract.[1]
- During the motility process, the production of flagella markedly increases, and the organism changes from a single-cell, rod-shaped form (swimmer) to a multi-cell, elongated-form (swarmer).[2][1]
- In the bladder, Proteus uses fimbriae and adhesins to bind to mucosal surfaces:[1]
- Mannose-resistant fimbriae (MRF)
- P. mirabilis fimbriae (PMF)
- Ambient temperature fimbiae
- Non-agglutinating fimbiae
- P-like pilus
Evasion of Host Defenses
- Production of an IgA-degrading protease which functions to cleave the secretory IgA.
- Expression of flagellin to synthesize flagella that provides the characteristic swarming motility of Proteus.
- Expression of the MR/P fimbriae
- Production of urease (increases pH) to provide an adequate medium for bacterial growth. Urease production is also associated with stone formation in the kidneys and the bladder.[3]
- Production of hemolysin, a cytotoxin involved in injury of host epithelial cells are known to cause damage to host epithelial cells. As mentioned above, urease can damage host epithelial cells through the formation of stones. Hemolysin damages cells
Stone Formation
- Proteus produces urease, which catalyzes the hydrolysis of urea tot ammonia and carbon dioxide.[4]
- The ammonia results in an increase in the local pH of the urinary tract, resulting in the precipitation of magnesium and calcium ions and subsequent formation of struvite (composed of magnesium ammonioum phosphate) and carbonate hydroxyapatite stones.[4][5][3]
- Proteus is able to sequester in the stone cavities and replicate while avoiding host defenses and therapeutic agents.[5]
References
- ↑ 1.0 1.1 1.2 1.3 Schaffer JN, Pearson MM (2015). "Proteus mirabilis and Urinary Tract Infections". Microbiol Spectr. 3 (5). doi:10.1128/microbiolspec.UTI-0017-2013. PMC 4638163. PMID 26542036.
- ↑ 2.0 2.1 Coker C, Poore CA, Li X, Mobley HL (2000). "Pathogenesis of Proteus mirabilis urinary tract infection". Microbes Infect. 2 (12): 1497–505. PMID 11099936.
- ↑ 3.0 3.1 Griffith DP, Musher DM, Itin C (1976). "Urease. The primary cause of infection-induced urinary stones". Invest Urol. 13 (5): 346–50. PMID 815197.
- ↑ 4.0 4.1 Mobley HL, Island MD, Hausinger RP (1995). "Molecular biology of microbial ureases". Microbiol Rev. 59 (3): 451–80. PMC 239369. PMID 7565414.
- ↑ 5.0 5.1 Dumanski AJ, Hedelin H, Edin-Liljegren A, Beauchemin D, McLean RJ (1994). "Unique ability of the Proteus mirabilis capsule to enhance mineral growth in infectious urinary calculi". Infect Immun. 62 (7): 2998–3003. PMC 302911. PMID 8005688.