Langerhans cell histiocytosis historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

Overview

The clinical presentation of Langerhans cell histiocytosis was first described by Dr. Alfred Hand Jr., an American pediatrician, in 1893. The term Langerhans cell histocytosis was first used to describe the disease by Dr. Sidney Farber, a pathologist at Boston Children Hospital, in 1941.

Historical Perspective

• The clinical presentation of Langerhans cell histiocytosis was first described by Alfred Hand Jr., an American pediatrician, in 1893.
• The term Hand-Schüller-Christian disease was first used to describe the clinical entity following the work of Dr. Artur Schüller and Dr. Henry Christian.
• Between the years 1920 and 1940, Dr. Erich Letterer and Dr. Sture Siwe used the term eosinophilic granuloma (Letterer–Siwe disease) to describe a similar clinical entity of the disease.
• It was not until the year 1941 that Dr. Sidney Farber, a pathologist at Boston Children Hospital, unified the clinically similar conditions under the term Langerhans cell histocytosis (histiocytosis X).
• Following the advances of electron microscopy, the term Birbeck granules was first used to describe the characteristic particles found in Langerhan cells in 1961.
• The phagocytic nature of Langerhan cells was first described in 1973 by Dr Christian Nezelof .

References

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