Langerhans cell histiocytosis differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

Overview

Langerhans cell histiocytosis must be differentiated from other diseases that cause bone pain, cutaneous lesions, hepatosplenomegaly, and palpable lymph nodes, such as cat-scratch disease, lymphoma, sinus histiocytosis with massive lymphadenopathy.

Differentiating Langerhans cell histiocytosis from other Diseases

• Langerhans cell histiocytosis must be differentiated from other diseases that cause bone pain, cutaneous lesions, hepatosplenomegaly, and palpable lymph nodes, such as:

• Lymphoma
• Cat-scratch disease
• Hypersensitivity reaction
• Erdheim-Chester disease: CD1a negative, focal S100+, no Birbeck granules
• Sinus histiocytosis with massive lymphadenopathy
• Kimura disease

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