Langerhans cell histiocytosis history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
Features can be non-specific from generalized inflammatory response e.g fever, lethargy, weight loss or can be due to specific organ involvement.
Symptoms
- Histiocytosis X often affects the whole body. A disease that affects the whole body is called a systemic disorder.
- Symptoms can vary between children and adults, although there can be some overlap. Tumors in weight-bearing bones, such as the legs or spine, may cause the bones to fracture without apparent reason.
- Symptoms in children may include:
- Abdominal pain
- Bone pain (possibly)
- Delayed puberty
- Dizziness
- Ear drainage that continues long-term
- Eyes that appear to stick out (protrude) more and more
- Irritability
- Failure to thrive
- Fever
- Frequent urination
- Headache
- Jaundice
- Limping
- Mental deterioration
- Rash (petechiae or purpura)
- Seborrheic dermatitis of the scalp
- Seizures
- Short stature
- Swollen lymph glands
- Thirst
- Vomiting
- Weight loss
Note: Children over 5 years old often have only bone involvement.
- Symptoms in adults may include:
- Bone pain
- Chest pain
- Cough
- Fever
- General discomfort, uneasiness, or ill feeling (malaise)
- Increased amount of urine
- Rash
- Shortness of breath
- Thirst and increased drinking of fluids
- Weight loss