Epithelioid sarcoma natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Natural History

The symptoms of epithelioid sarcoma usually develop in the second decade of life, and start with symptoms such as mass. Epitheliod sarcoma has a tendency for lymph node metastasis. The most common sites of epithelioid metastasis include lungs, lymph nodes, and scalp.

Complications

• Metastasis
• Contractures
• Nerve compression
• Muscle weakness
• Numbness

Prognosis

• The prognosis of epithelioid sarcoma is good for females.
• Five year survival rate for patients with epithelioid sarcoma is approximately 50-70%
• Ten year survival rate for patients with epithelioid sarcoma is approximately 42-55%
• Prognosis varies with:

• Age of diagnosis- Earlier age of diagnosis is associated with better outcome
• Gender
• Site- Proximal leisons have worse prognosis
• Microscopic pathology- Necrosis and vascular invasion have been associated with poor prognosis
• Tumor size- Tumors of more than 2 cm size has been associated with poor prognosis
• Mitotic index

References

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