Primary central nervous system lymphoma differential diagnosis
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Primary central nervous system lymphoma Microchapters |
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Differentiating Primary Central Nervous System Lymphoma from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Differentiating Primary Central Nervous System Lymphoma from other Diseases
Primary central nervous system lymphoma must be differentiated from:[1]
- Secondary CNS lymphoma: indistinguishable on imaging, however it tends to involve more leptomeninges (~2/3 of cases)
- Cerebral toxoplasmosis
- Glioblastoma multiforme (butterfly glioma)
- Tumefactive demyelinating lesion
- Cerebral abscess
- Neurosarcoidosis
It is a relatively common occurrence for radiologists to be asked to distinguish between cerebral toxoplasmosis and primary central nervous system lymphoma in patients with HIV/AIDS. Treatment is clearly different and thus accurate interpretation of CT and MRI is essential.[2] In many instances appearances are classic and pose little problem, however, in 50-80% of cases the appearances can be very similar requiring careful interpretation 1. Below are helpful distinguishing features.[2]
| Differentiating point | Primary CNS Lymphoma | Cerebral Toxoplasmosis |
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References
- ↑ Differential diagnosis of primary central nervous system lymphoma. Dr Amir Rezaee and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/articles/primary-cns-lymphoma. Accessed on February 17, 2016
- ↑ 2.0 2.1 Toxoplasmosis vs CNS lymphoma. Dr Henry Knipe and Dr Praveen Jha et al. Radiopaedia 2016. http://radiopaedia.org/articles/toxoplasmosis-vs-lymphoma. Accessed on February 17, 2016