Mucoepidermoid carcinoma natural history

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]

Overview

If left untreated, patients with mucoepidermoid carcinoma may progress to develop centinel metastasis to adjacent structures. Common complications mucoepidermoid carcinoma include facial deformity. Prognosis will generally depend on the clinical stage, tumor size, and histological grade. The recurrence rate of mucoepidermoid carcinoma will also depend on the stage, the majority of patients in advanced stage have a 75-80% recurrence rate.^[1]

Natural History

Most patients with mucoepidermoid carcinoma are initially asymptomatic.
The symptoms of usually develop in the second or fifth decade of life, and initially patients complain of swallowing problems that is increased upon chewing activity.
If left untreated, patients with mucoepidermoid carcinoma may progress to develop centinel metastasis to adjacent structures.

Complications

Common complications of mucoepidermoid carcinoma, include:^[1]

Facial deformity

Prognosis

Prognosis will generally depend on the clinical stage, tumor size, and histological grade.
The overall recurrence rate will depend on the stage^[1]
Low grade tumors have a 90-98% survival and a low local recurrence rate
High grade tumors 30-54% surviving, and a high local recurrence rate ^[2]

References

↑ ^1.0 ^1.1 ^1.2 Plambeck K, Friedrich RE, Schmelzle R (1996). "Mucoepidermoid carcinoma of salivary gland origin: classification, clinical-pathological correlation, treatment results and long-term follow-up in 55 patients". J Craniomaxillofac Surg. 24 (3): 133–9. PMID 8842902.
↑ Armstrong JG, Harrison LB, Spiro RH, Fass DE, Strong EW, Fuks ZY (1990). "Malignant tumors of major salivary gland origin. A matched-pair analysis of the role of combined surgery and postoperative radiotherapy". Arch. Otolaryngol. Head Neck Surg. 116 (3): 290–3. PMID 2306346.

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[pmid8842902-1] 1.0 ^1.1 ^1.2 Plambeck K, Friedrich RE, Schmelzle R (1996). "Mucoepidermoid carcinoma of salivary gland origin: classification, clinical-pathological correlation, treatment results and long-term follow-up in 55 patients". J Craniomaxillofac Surg. 24 (3): 133–9. PMID 8842902.

[pmid2306346-2] Armstrong JG, Harrison LB, Spiro RH, Fass DE, Strong EW, Fuks ZY (1990). "Malignant tumors of major salivary gland origin. A matched-pair analysis of the role of combined surgery and postoperative radiotherapy". Arch. Otolaryngol. Head Neck Surg. 116 (3): 290–3. PMID 2306346.

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