Mast cell tumor pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pathophysiology
Mast cells are bone marrow derived cells that are widely distributed in tissues. They store various biologically active mediators, such as heparin and histamine. Mediator release from mast cells has a central role in the development of type 1 hypersensitivity 1.
In systemic mastocytosis, abnormal proliferation and microscopic infiltration of mast cells involves skin, bone marrow, gastrointestinal tract, liver and spleen. It is thought that the effects of mastocytosis relate at least in part to mediator release 7.
- A mast cell originates from the bone marrow and is normally found throughout the connective tissue of the body.
- It is a normal component of the immune system and as it releases histamine it is associated with allergic reactions.
- Mast cell granules contain histamine, heparin, platelet-activating factor, and other substances.[1] with a similar number in cats.[2]
References
- ↑ Brière C (2002). "Use of a reverse saphenous skin flap for the excision of a grade II mast cell tumor on the hind limb of a dog". Can Vet J. 43 (8): 620–2. PMID 12170840.
- ↑ Johnson T, Schulman F, Lipscomb T, Yantis L (2002). "Histopathology and biologic behavior of pleomorphic cutaneous mast cell tumors in fifteen cats". Vet Pathol. 39 (4): 452–7. PMID 12126148.