Mast cell tumor history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

History and Symptoms

MPCM (urticaria pigmentosa) is the most common clinical variant in which fixed, reddish brown lesions occurring as maculo-papules, plaques, nodules or blisters are found. These lesions urticate in response to physical irritation (Darier’s sign). Urticaria Pigmentosa (UP) lesions tend to be larger, better delineated, and more hyperpigmented in children, as compared to adults, who tend to have numerous small lesions that coalesce to form mottled areas. The trunk and thigh are more commonly involved with sparing of face, palms and soles.