Primary cutaneous follicle centre lymphoma pathophysiology
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Primary cutaneous follicle centre lymphoma Microchapters |
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Differentiating Primary cutaneous follicle centre lymphoma from other Diseases |
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Diagnosis |
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Treatment |
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Primary cutaneous follicle centre lymphoma pathophysiology On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
Pathophysiology
Gross Pathology
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![Multinodular mass on the scalp (A) and spectacular response after the second chemotherapy course (B).[1]](/images/6/6d/Primary_cutaneous_follicle_centre_lymphoma_images.jpg)
Multinodular mass on the scalp (A) and spectacular response after the second chemotherapy course (B).[1]
![Multinodular mass on the scalp (A) and spectacular response after the second chemotherapy course (B).[1]](/index.php/File:Primary_cutaneous_follicle_centre_lymphoma_images.jpg)
Microscopic Pathology
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![Histopatological fingings. Biopsy of the mass of the scalp showing a dense and diffuse dermal infiltrate with nodular growth pattern (A) consisted of large atypical lymphocytes (H&E) (B), which are positive for CD20 (C) and Bcl6 (D) and negative for Bcl2 (E) on immunohistochemical staining. Bone marrow biopsy showing a hypercellular bone marrow with proliferation of megakaryocytes with hyperlobulated nuclei, sometimes in loose clusters (H&E) (F), positive for CD61 on immunohistochemical staining (G).[1]](/images/2/21/Primary_cutaneous_follicle_centre_lymphoma_image_2.jpg)
Histopatological fingings. Biopsy of the mass of the scalp showing a dense and diffuse dermal infiltrate with nodular growth pattern (A) consisted of large atypical lymphocytes (H&E) (B), which are positive for CD20 (C) and Bcl6 (D) and negative for Bcl2 (E) on immunohistochemical staining. Bone marrow biopsy showing a hypercellular bone marrow with proliferation of megakaryocytes with hyperlobulated nuclei, sometimes in loose clusters (H&E) (F), positive for CD61 on immunohistochemical staining (G).[1]
![Histopatological fingings. Biopsy of the mass of the scalp showing a dense and diffuse dermal infiltrate with nodular growth pattern (A) consisted of large atypical lymphocytes (H&E) (B), which are positive for CD20 (C) and Bcl6 (D) and negative for Bcl2 (E) on immunohistochemical staining. Bone marrow biopsy showing a hypercellular bone marrow with proliferation of megakaryocytes with hyperlobulated nuclei, sometimes in loose clusters (H&E) (F), positive for CD61 on immunohistochemical staining (G).[1]](/index.php/File:Primary_cutaneous_follicle_centre_lymphoma_image_2.jpg)
References
- ↑ 1.0 1.1 Primary cutaneous follicle centre lymphoma. BioMed Central. https://biomarkerres.biomedcentral.com/articles/10.1186/2050-7771-2-7. Accessed on March 01, 2016