Primary cutaneous follicle centre lymphoma pathophysiology

Primary cutaneous follicle centre lymphoma Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Pathophysiology

Primary cutaneous follicle center lymphoma (PCFCL) is characterized by a proliferation of follicle center cells (centrocytes and centroblasts) with a follicular, follicular and diffuse, or diffuse growth pattern.]]

Genetics

Genes involved in the pathogenesis of primary cutaneous follicle centre lymphoma include:

• Amplification of C-REL gene
• BCL-2 rearrangements

Gross Pathology

Multinodular mass on the scalp (A) and spectacular response after the second chemotherapy course (B).

Microscopic Pathology

Histopatological fingings. Biopsy of the mass of the scalp showing a dense and diffuse dermal infiltrate with nodular growth pattern (A) consisted of large atypical lymphocytes (H&E) (B), which are positive for CD20 (C) and Bcl6 (D) and negative for Bcl2 (E) on immunohistochemical staining. Bone marrow biopsy showing a hypercellular bone marrow with proliferation of megakaryocytes with hyperlobulated nuclei, sometimes in loose clusters (H&E) (F), positive for CD61 on immunohistochemical staining (G).

References

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