Seminoma pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Gross Pathology

On gross pathology, seminoma is characterized by pale gray to yellow nodules that are uniform or slightly lobulated and often bulge from the cut surface.

Microscopic Pathology

• On microscopic pathology, seminoma is characterized by:

• Cells with fried egg appearance - key feature

• Clear cytoplasm
• Central nucleus, with prominent nucleolus. Nucleus may have "corners", i.e. it is not round.

• Lymphocytes - interspersed (common)
• Syncytiotrophoblasts, present in ~10-20% of seminoma

• Large, irregular, vesicular nuclei
• Eosinophilic vacuolated cytoplasm (contains hCG)

• Florid granulomatous reaction

• Approximately 24% of Stage I seminomas have lymphovascular invasion for stage I (Tx, N0, M0).
• Intertubular seminoma may not form a discrete mass and mimic a benign testis.

Gallery

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  _{Microscopic image of seminoma demonstrating fried egg-like cells (clear or eosinophilic cytoplasm, central nucleus) and lymphocytic infiltrate.}