Myelofibrosis natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Complications

Common complications of myelofibrosis include:

• Acute myelogenous leukemia
• Infections
• Bleeding
• Blood clots
• Hepatic failure
• Gout

Prognosis

Myelofibrosis leads to progressive bone marrow failure. The mean survival is five years and causes of death include infection, bleeding, organ failure, portal hypertension, and leukemic transformation.

References

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