Thrombophilia epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Epidemiology and Demographics
Prevalence of various inherited thrombophilias and their clinical impact
| Disorder | Healthy subjects/General population (%) | Patients with known thrombosis (%) | Estimated increase in thrombosis risk |
|---|---|---|---|
| Antithrombin deficiency | 0.02 | 1 - 4 | 10 - 20X |
| Dysfibrinogenemia | <1 | <1 | Variable |
| Protein C deficiency | 0.2 - 0.4 | 3 - 5 | 10X |
| Protein S deficiency | 0.3 - 0.13 | 2 - 4 | 10X |
| Factor V Leiden | 1 - 15 | 18 - 40 | 5X |
| G20210A prothrombin gene mutation | 2 - 5 | 7 - 16 | 3X |
| Hyperhomocystenemia | 5 | 10 | 3X |
| Elevated factor VIII levels | 11 | 25 | 5X |
The table has been adapted from Best Pract Res Clin Obstet Gynaecol. 2003 Jun;17(3):397-411[1] and data has been obtained from references[2][3][4].
References
- ↑ Buchanan GS, Rodgers GM, Ware Branch D (2003). "The inherited thrombophilias: genetics, epidemiology, and laboratory evaluation". Best Pract Res Clin Obstet Gynaecol. 17 (3): 397–411. PMID 12787534. Unknown parameter
|month=ignored (help) - ↑ Seligsohn U, Lubetsky A (2001). "Genetic susceptibility to venous thrombosis". N. Engl. J. Med. 344 (16): 1222–31. doi:10.1056/NEJM200104193441607. PMID 11309638. Unknown parameter
|month=ignored (help) - ↑ Franco RF, Reitsma PH (2001). "Genetic risk factors of venous thrombosis". Hum. Genet. 109 (4): 369–84. doi:10.1007/s004390100593. PMID 11702218. Unknown parameter
|month=ignored (help) - ↑ Haverkate F, Samama M (1995). "Familial dysfibrinogenemia and thrombophilia. Report on a study of the SSC Subcommittee on Fibrinogen". Thromb. Haemost. 73 (1): 151–61. PMID 7740487. Unknown parameter
|month=ignored (help)