Thrombophilia differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Asiri Ediriwickrema, M.D., M.H.S. [2]

Overview

• Inherited thrombophilia must be differentiated from acquired thrombophilia, as it may influence the selection and duration of anticoagulation.
• Inherited thrombophilias should be suspected in patients with the certain clinical presentations.
• Screening for inherited thrombophilias is controversial and should be performed in the appropriate clinical context.

Differential Diagnosis

• Inherited thrombophilias should be suspected in following clinical presentations:
  • Family history of thrombosis, especially at an early age
  • Unprovoked thrombosis at an early age (<40-55 for venous thrombosis and <50-55 for arterial thrombosis)
  • Recurrent thrombosis
  • Thrombosis at multiple sites, or unusual locations including in cerebral, splanchnic, and renal veins.
  • Thrombosis in arteries with the abscence of arterial disease
  • History of fetal loss