Primary sclerosing cholangitis causes
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Differentiating Primary sclerosing cholangitis from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Causes
The cause(s) for PSC are unknown. It is often considered to be an autoimmune disorder. PSC is associated with ulcerative colitis. It is assumed that these diseases share a common cause.
Ulcerative colitis is a systemic disease that affects many areas of the body. PSC is often listed as a manifestation of ulcerative colitis outside the colon. PSC differs from these manifestations in that, unlike most other manifestations, PSC continues in spite of surgical removal of the colon.[2] This suggests that, while the cause of ulcerative colitis, and most of its manifestations, is in the colon, the cause of PSC is located outside the colon.