DRESS syndrome epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Yazan Daaboul, M.D.; Serge Korjian M.D.

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Overview

The incidence of DRESS syndrome is approximately 10 to 100 per 100,000 drug exposures. The case-fatality rate of DRESS syndrome is approximately 10%. DRESS syndrome has been reported among patients of all ages with no gender or racial predilection.

Epidemiology and Demographics

Incidence

The incidence of DRESS syndrome is approximately 10 to 100 per 100,000 drug exposures.^[1]

Case-Fatality Rate

The case-fatality rate of DRESS syndrome is approximately 10%.

Age

DRESS syndrome affects patients of all ages and has been reported among pediatric, adult, and elderly patients.^[1]
In modest-sized observational studies and case series:

The median age for the development of DRESS syndrome is approximately 40-50 years among adult patients.^[2]^[3]
The median age for the development of DRESS syndrome is approximately 10-12 years among pediatric patients.^[4]

Gender

There is no gender predilection to the development of DRESS syndrome.

Race

There is no racial predilection to the development of DRESS syndrome.

References

↑ ^1.0 ^1.1 Fiszenson-Albala F, Auzerie V, Mahe E, Farinotti R, Durand-Stocco C, Crickx B; et al. (2003). "A 6-month prospective survey of cutaneous drug reactions in a hospital setting". Br J Dermatol. 149 (5): 1018–22. PMID 14632808.
↑ Cacoub P, Musette P, Descamps V, Meyer O, Speirs C, Finzi L; et al. (2011). "The DRESS syndrome: a literature review". Am J Med. 124 (7): 588–97. doi:10.1016/j.amjmed.2011.01.017. PMID 21592453.
↑ Chen YC, Chiu HC, Chu CY (2010). "Drug reaction with eosinophilia and systemic symptoms: a retrospective study of 60 cases". Arch Dermatol. 146 (12): 1373–9. doi:10.1001/archdermatol.2010.198. PMID 20713773.
↑ Carroll MC, Yueng-Yue KA, Esterly NB, Drolet BA (2001). "Drug-induced hypersensitivity syndrome in pediatric patients". Pediatrics. 108 (2): 485–92. PMID 11483822.

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[pmid14632808-1] 1.0 ^1.1 Fiszenson-Albala F, Auzerie V, Mahe E, Farinotti R, Durand-Stocco C, Crickx B; et al. (2003). "A 6-month prospective survey of cutaneous drug reactions in a hospital setting". Br J Dermatol. 149 (5): 1018–22. PMID 14632808.

[pmid21592453-2] Cacoub P, Musette P, Descamps V, Meyer O, Speirs C, Finzi L; et al. (2011). "The DRESS syndrome: a literature review". Am J Med. 124 (7): 588–97. doi:10.1016/j.amjmed.2011.01.017. PMID 21592453.

[pmid20713773-3] Chen YC, Chiu HC, Chu CY (2010). "Drug reaction with eosinophilia and systemic symptoms: a retrospective study of 60 cases". Arch Dermatol. 146 (12): 1373–9. doi:10.1001/archdermatol.2010.198. PMID 20713773.

[pmid11483822-4] Carroll MC, Yueng-Yue KA, Esterly NB, Drolet BA (2001). "Drug-induced hypersensitivity syndrome in pediatric patients". Pediatrics. 108 (2): 485–92. PMID 11483822.

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