Bleb-related endophthalmitis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mehrsefat, M.D. [2]

Overview

Bleb-related endophthalmitis (BRE) is the second most frequent cause of postoperative endophthalmitis after acute and chronic post-cataract surgery endophthalmitis.

Epidemiology and Demographics

The incidence of bleb-related endophthalmitis is approximately range from 200 to 1300 per 100,000 individuals with . It's incidence is reported to be between 0.2% to 1.3%,2,3 and is more common with the use of antiproliferative agent (up to 3%) and even higher when the bleb is placed inferiorly (up to 9.4%).

Risk Factors

• Bleb leakage (increase the risk of bleb infection 26 fold)
  • General conjunctival thinning
  • Reduced cellularity
  • Avascular bleb
  • Use of anti-metabolites (such as [[5-fluorouracil|5-fluorouracil (5-FU))
  • Use of Mitomycn-C (MMC)

Natural History, Complications, and Prognosis

Prognosis

A single-center retrospective review from the 1990s showed that the 5 year risk of blebitis and that of BAE is 6.3% and 7.5%, respectively.

References

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