Typhoid fever classification
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aysha Anwar, M.B.B.S[2]
Overview
There is no established classification system for typhoid fever. However, typhoid fever may be classified
Classification
There is no established classification system for typhoid fever. However, typhoid fever may be classified as follows
Duration of illness
Acute disease
- Sudden in onset
- Severe by nature
- Lasts < 12 months
- Mostly symptomatic
Chronic disease
- Lasts > 12 months
- Less severe
- Asymptomatic
Serological type
Salmonella enterica serotype typhi
- causes classic typhoid fever syndrome
other serotypes
- causes typhoid fever like syndrome
- Salmonella paratyphi A
- Salmonella paratyphi B
- Salmonella paratyphi C
- Salmonella choleraesuis
Severity of illness
Mild disease
Moderate to severe disease
Virulence factors
High virulence factors
- PhoP/phoQ genes
- CdtB protein
- Vi antigen positive strains
Low virulence factors
- Absence of above factors
- Presence of following host factors
- C282 mutation
- CFTR mutation