Allergic colitis laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Qasim Salau, M.B.B.S., FMCPaed [2]

Laboratory Findings

There are no specific diagnostic laboratory findings associated with allergic colitis. Routine laboratory studies should be correlated with a carefully taken history and a detailed physical examination.

Stool microscopy

May shows presence of increased eosinophils which is suggestive of allergic colitis in the presence of typical clinical findings

Complete Blood Count with Differentials and Peripheral Blood Smear

• A low hemoglobin or hematocrit with microcytosis or marginal normocytosis may be seen and indicative of iron deficiency anemia from blood loss
• Peripheral blood eosinophilia may rarely be seen especially in FPIES
• Elevated white blood cells with a left shift may be seen in severe acute FPIES

Iron studies

• Low ferritin with a high TIBC is suggestive of chronic blood loss by inflammatory bowel disease.
• High ferritin may be suggestive of anemia of chronic inflammatory conditions

Complete Metabolic Panel

• May show hypoalbuminemia especially in children with chronic FPIES
• Metabolic acidosis may be seen with FPIES