Chronic stable angina treatment diabetes control
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Chronic stable angina Microchapters | ||
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Classification | ||
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Differentiating Chronic Stable Angina from Acute Coronary Syndromes | ||
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Diagnosis | ||
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Alternative Therapies for Refractory Angina | ||
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Discharge Care | ||
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Guidelines for Asymptomatic Patients | ||
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Case Studies | ||
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Chronic stable angina treatment diabetes control On the Web | ||
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Chronic stable angina treatment diabetes control in the news | ||
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Risk calculators and risk factors for Chronic stable angina treatment diabetes control | ||
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [3] Phone:617-632-7753; Associate Editor(s)-In-Chief: Lakshmi Gopalakrishnan, M.B.B.S.
Overview
Diabetes is one of the major modifiable risk factors for coronary artery disease. Maintaining a good glycemic control has been demonstrated to delay the disease progression in patients with impaired glycemic control and further prevent microvascular complications.[1][2][3] In type 1 diabetics, appropriate insulin therapy and concomitant dietary modification may be required. However, in patients with type 2 diabetes, a multi-factorial intervention involving increased physical activity, weight reduction, dietary modification and/or drug therapy has shown to reduce the risk of overall cardiovascular and microvascular events by approximately 50%.[4][5]
Diabetes Control
Supportive Trial Data
- The PROactive study, a prospective, randomized control trial of 5,238 patients with type 2 diabetes and evidence of macrovascular disease, assed the efficacy of pioglitazone on macrovascular morbidity and mortality in high-risk patients with type 2 diabetes. Researchers reported a significant reduction in the incidence of composite primary endpoint that included death or non-fatal MI. Findings also suggested that the addition of pioglitazone to other hypoglycemic agents provided better overall clinical outcomes.[6]
- The Steno-2 study, a randomized parallel trial of 160 patients who either received conventional treatment based on national guidelines or intensive treatment involving behavior modification and pharmacologic therapy, assessed the effect of multi-factorial intervention in patients with type 2 diabetes and microalbuminuria. Researchers demonstrated a significant reduction in the risk of cardiovascular disease (hazard ratio: 0.47; 95% CI, 0.24, 0.73) and nephropathy (hazard ratio: 0.39; 95% CI, 0.17, 0.87). It was reported that when a target-driven, long-term, multi-factorial intervention was applied to patients with type 2 diabetes and microalbuminuria the risk of cardiovascular disease could be reduced by approximately 50%.[5]
2007 Chronic Angina Focused Update of the ACC/AHA 2002 Guidelines for the Management of Patients With Chronic Stable Angina (DO NOT EDIT)[7][8]
Diabetes Management (DO NOT EDIT)[7][8]
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| "1. Diabetes management should include lifestyle and pharmacotherapy measures to achieve a near-normal HbA1c. (Level of Evidence: B) " |
| "2. Vigorous modification of other risk factors (e.g., physical activity, weight management, blood pressure control, and cholesterol management) as recommended should be initiated and maintained. (Level of Evidence: B) " |
References
- ↑ European Society of Hypertension-European Society of Cardiology Guidelines Committee (2003) 2003 European Society of Hypertension-European Society of Cardiology guidelines for the management of arterial hypertension. J Hypertens 21 (6):1011-53. DOI:10.1097/01.hjh.0000059051.65882.32 PMID: 12777938
- ↑ American Diabetes Association (2003) Standards of medical care for patients with diabetes mellitus. Diabetes Care 26 Suppl 1 ():S33-50. PMID: 12502618
- ↑ Inzucchi SE, Amatruda JM (2003) Lipid management in patients with diabetes: translating guidelines into action. Diabetes Care 26 (4):1309-11. PMID: 12663615
- ↑ De Backer G, Ambrosioni E, Borch-Johnsen K, Brotons C, Cifkova R, Dallongeville J et al. (2003) European guidelines on cardiovascular disease prevention in clinical practice. Third Joint Task Force of European and Other Societies on Cardiovascular Disease Prevention in Clinical Practice. Eur Heart J 24 (17):1601-10. PMID: 12964575
- ↑ 5.0 5.1 Gaede P, Vedel P, Larsen N, Jensen GV, Parving HH, Pedersen O (2003) Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes. N Engl J Med 348 (5):383-93. DOI:10.1056/NEJMoa021778 PMID: 12556541
- ↑ Dormandy JA, Charbonnel B, Eckland DJ, Erdmann E, Massi-Benedetti M, Moules IK et al. (2005) Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial. Lancet 366 (9493):1279-89. DOI:10.1016/S0140-6736(05)67528-9 PMID: 16214598
- ↑ 7.0 7.1 Gibbons RJ, Abrams J, Chatterjee K, Daley J, Deedwania PC, Douglas JS et al. (2003) ACC/AHA 2002 guideline update for the management of patients with chronic stable angina--summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on the Management of Patients With Chronic Stable Angina). Circulation 107 (1):149-58.[1] PMID: 12515758
- ↑ 8.0 8.1 Fraker TD, Fihn SD, Gibbons RJ, Abrams J, Chatterjee K, Daley J et al. (2007)2007 chronic angina focused update of the ACC/AHA 2002 Guidelines for the management of patients with chronic stable angina: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines Writing Group to develop the focused update of the 2002 Guidelines for the management of patients with chronic stable angina. Circulation 116 (23):2762-72.[2] PMID: 17998462