Differentiating Churg-Strauss syndrome from other diseases

Churg-Strauss syndrome Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2]Associate Editor(s)-in-Chief: Krzysztof Wierzbicki M.D. [3]

Overview

Eosinophilic granulomatosis with polyangiits must be differentiated from other diseases that can cause purpura, alveolar hemorrhage, fever, arthralgia, myalgia, necrotizing extra-capillary glomerulonephritis, such as Granulomatosis with polyangiitis and Microscopic polyangiitis.

Differentiating Eosinophilic granulomatosis with polyangiitis from other Diseases

• Differentiation of Churg-Strauss syndrome from Wegener's granulomatosis can be difficult, though the increasing use of ANCA assays has made the distinction more routine. Wegener's is closely associated with c-ANCA, unlike Churg-Strauss which shows elevations of p-ANCA.
• Churg-Strauss syndrome was once considered a type of Polyarteritis nodosa (PAN) due to their similar morphologies.