Brucellosis differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Danitza Lukac

Overview

Brucellosis must be differentiated from typhoid fever, malaria, tuberculosis, lymphoma, dengue, leptospirosis and rheumatic diseases.

Differentiating Brucellosis from other Diseases[edit | edit source]

Differentiating Brucellosis from other Diseases

Differential Diagnosis	Distinguishing Clinical Features
Typhoid fever	High persistent fevers (104-105°F), particularly vespertine + constipation + relative bradycardia
Malaria	Intermittent fever + chills + sweating + anorexia + nausea + cephalalgia + myalgia + normal CBC or thrombocytopenia and/or hemolytic anemia + hyperbilirubinemia + normal or mild elevated erythrocyte sedimentation rate + hepatosplenomegaly
Tuberculosis	Night sweats + weight loss + dry or productive cough.
Lymphoma	Painless superficial lymphadenopathy (cervical, supraclavicular, axillary or inguinal) + fever + night sweats + asthenia + weight loss + generalized pruritus
Dengue	Fever + cephalalgia + retro orbital pain + myalgias + abdominal pain + arthralgia + cutaneous eruption + hemorrhagic manifestations
Leptospirosis	Jaundice with no hepatosplenomegaly + leukocytosis + neutrophilia + elevated erythrocyte sedimentation rate
Rheumatic Diseases	Protracted fever + weight loss + polyadenopathy + cough + thoracic pain + hemoptysis + dysphonia + weakness + ocular lesions.