Epididymoorchitis overview
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dima Nimri, M.D. [2]
Overview
Historical Perspective
Cases of epididymoorchitis were described in literature as early as 1841.[1]It was believed that epididymitis was caused by chemical irritation caused by urine reflux. However, by 1979, a study showed that bacteria were responsible for more cases. [2]
Classification
Epididymoorchitis can be classified based on the extent of involvement into isolated cases of epididymitis, isolated cases of orchitis or cases of epididymoorchitis. Another means of classifying the disease is based on duration into acute or chronic epididymoorchitis. Finally, it can also be classified according to the causative agent into infectious, non-infectious and idiopathic causes.[2][3]
Pathophysiology
Epididymoorchitis refers to the inflammation of the epididymis and/or testes, with or without infection. While the pathogenesis is not fully understood, infectious epididymoorchitis is thought to be due to retrograde reflux of infected urine into the epididymis, which then spreads to the testes.[2][3]
Causes
The causes of epididymoorchitis can be divided into idiopathic, infectious and non-infectious causes.[4][3]
Differentiating Epididymoorchitis from other Diseases
Epididymoorchitis is a major cause of acute scrotum. Other causes of acute scrotum which must be differentiated from epididymoorchitis include testicular torsion and torsion of the testicular appendage.[2][5][4][6]
Epidemiology and Demographics
Data on epidemiology of epididymoorchitis is scarce, however, epididymoorchitis is the 5th most common genitourinary diagnosis made and disease is more prevalent among U.S. military men. Peak incidence of the disease is in men between the ages of 20 to 29 years.[4]
Risk Factors
Risk factors for epididymoorchitis include sexual activity and sexually transmitted diseases, surgery or instrumentation of the bladder, as well as anatomic abnormalities of the urinary tract and obstruction to the normal flow of urine.[2]
Screening
There are no screening recommendations for epididymoorchitis.[7]
Natural History, Complications and Prognosis
History and Symptoms
The main symptoms of epididymoorchitis are scrotal pain and swelling. Other symptoms such as fever, nausea, vomiting and lower UTI symptoms may be present.[2][8][5][4]
Physical Examination
The main focus of physical examination in patients with epididymoorchitis is scrotal and testicular examination. Signs that may be present include testicular swelling, tenderness on palpation, as well as erythema. Other signs include relief of pain upon elevation of the testis. Unlike patients with testicular torsion, patients with epididymoorchitis have an intact cremasteric reflex.
Laboratory Findings
In patients with epididymoorchitis, laboratory investigations include a urinalysis, urine culture, as well as urethral Gram stain and PCR testing for N. gonorrhea and C. trachomatis.
X Ray
There are no x-ray findings associated with epididymoorchitis.
CT
Imaging studies, such as CT scan, are usually not done in the case of epididymoorchitis. The diagnostic modality of choice is a scrotal ultrasound.
MRI
Imaging studies, such as MRI, are usually not done in the case of epididymoorchitis. The diagnostic modality of choice is a scrotal ultrasound.
Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
References
- ↑ Taylor AJ (1841). "On the utility of compression in epididymitis: With cases". Prov Med Surg J (1840). 3 (53): 8–10. PMC 2489278. PMID 21379715.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Trojian TH, Lishnak TS, Heiman D (2009). "Epididymitis and orchitis: an overview". Am Fam Physician. 79 (7): 583–7. PMID 19378875.
- ↑ 3.0 3.1 3.2 Tracy CR, Steers WD, Costabile R (2008). "Diagnosis and management of epididymitis". Urol. Clin. North Am. 35 (1): 101–8, vii. doi:10.1016/j.ucl.2007.09.013. PMID 18061028.
- ↑ 4.0 4.1 4.2 4.3 Luzzi GA, O'Brien TS (2001). "Acute epididymitis". BJU Int. 87 (8): 747–55. PMID 11350430.
- ↑ 5.0 5.1 Kadish HA, Bolte RG (1998). "A retrospective review of pediatric patients with epididymitis, testicular torsion, and torsion of testicular appendages". Pediatrics. 102 (1 Pt 1): 73–6. PMID 9651416.
- ↑ Ciftci AO, Senocak ME, Tanyel FC, Büyükpamukçu N (2004). "Clinical predictors for differential diagnosis of acute scrotum". Eur J Pediatr Surg. 14 (5): 333–8. doi:10.1055/s-2004-821210. PMID 15543483.
- ↑ The U.S. Preventive Services Task Force https://www.uspreventiveservicestaskforce.org/BrowseRec/Search?s=epididymoorchitis. Accessed on Dec. 28, 2016.
- ↑ Stewart A, Ubee SS, Davies H (2011). "Epididymo-orchitis". BMJ. 342: d1543. PMID 21490048.