Brucellosis diagnostic criteria

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Danitza Lukac

Overview

There is no specific diagnostic criteria for Brucellosis, Diagnosis is based on history of potential exposure, presentation consistent with the disease,Supporting laboratory findings.

Diagnostic Criteria

There is no specific diagnostic criteria for Brucellosis, Diagnosis is based on:

• History of potential exposure
• Presentation consistent with the disease
• Supporting laboratory findings

Diagnosis of brucellosis
History of potential exposure	Living or travelling to Brucellosis endemic countries Consuming unpasteurized dairy products or raw meat products Unsafe hunting practices Occupational risks such as slaughther house workers, meat-packing employees, and veterinarian
presentation consistent with the disease	An illness characterized by acute or insidious onset of fever and one or more of the following: Night sweats Arthralgia Headache Fatigue Anorexia Myalgia Weight loss Arthritis/spondylitis Meningitis Focal organ involvement (endocarditis, orchitis/epididymitis, hepatomegaly, splenomegaly)
Supporting laboratory findings	Definitive: Culture and identification of Brucella spp. from clinical specimens Evidence of a fourfold or greater rise in Brucella antibody titer between acute- and convalescent-phase serum specimens obtained greater than or equal to 2 weeks apart Presumptive: Brucella total antibody titer of greater than or equal to 160 by standard tube agglutination test (SAT) or Brucella microagglutination test (BMAT) in one or more serum specimens obtained after onset of symptoms Detection of Brucella DNA in a clinical specimen by PCR assay Other non-specific findings may include: Complete blood count: Normal or low with relative lymphocytosis. Low platelets may be reported Hemoglobin: Mild anemia is documented Normal or elevated ESR Normal or elevated C-reactive protein levels Raised fibrinogen degraded products