Fungal meningitis historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Prince Tano Djan, BSc, MBChB [2]

Historical perspective

The major advancements in the history of meningitis may be summarized as follows:

• C. neoformans, an encapsulated basidiomycetous yeast, represents one of the most common CNS pathogens encountered in clinical practice today.
• The first report of human cryptococcosis was published by Busse and Busckhe more than 100 years ago; 10 years later, it was identified as the cause of human meningitis.

• In 1661, Thomas Willis first described the inflammation of meninges and an epidemic of meningitis.
• In 1891, Heinrich Quincke provided an early analysis of CSF by introducing a new technique of lumbar puncture.
• In early 19th century, detailed profile of CSF analysis in meningitis was explained by William Mestrezat, and H. Houston Merritt.
• Advancements regarding the treatment of bacterial meningitis was given by Georg Joachmann in Germany and Simon Flexnor in USA in 18th and 19th century respectively