Pott's disease differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Hardik Patel, M.D.

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Overview

Pott's disease resembles the following disorders and needs to be differentiated from them:

Disease	Age of Presentation	Common site involved	Risk Factors	Clinical Features	Laboratory Findings	Imaging Findings
Pyogenic Abscess of the spine	Any age	Lumbar	Systemic illnesses like diabetes mellitus	Fever and marked back pain, myelopathy	Elevated ESR Elevated WBC's Elevated CRP	Destruction of vertebral bodies and disc spaces, marked enhancement of the lesion, epidural abscess
Pott's Disease	Children and adults	Lumbo-thoracic	Exposure to tuberculous infection	Fever, malaise and weight loss, backache, myelopathy	Elevated ESR Normal WBC	Destruction of vertebral bodies and disc spaces, rim enhancement of the soft-tissue masses
Brucella abscess of the spine	Adults	Lumbar	Ingestion of unpasteurized milk	Fever, malaise, weight loss, backache	Elevated ESR Elevated WBC Elevated CRP	Intact vertebral architecture despite diffuse vertebral osteomyelitis
Vertebral Metastasis	Elderly	Thoracic	Presence of systemic malignancy	Bone pain at night, backache, back pain followed by radicular pain, myelopathy	Normal WBC, ESR and CRP	Low signal intensity on T1-weighted images, hypersignal on T2-weighted images and heterogeneous enhancement