Chronic diarrhea medical therapy
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Chronic diarrhea Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Omodamola Aje B.Sc, M.D. [2]
Overview
Antidiarrheal drugs can be broadly defined as agents that minimize the symptoms of diarrhea by improving stool consistency, reducing stool frequency, or reducing stool weight.[1]
Medical Therapy
Antidiarrheal drugs are prescribed depending on the underlying mechanism for example, in a patient with Zollinger ellison syndrome (ZES) where hypersecretion of gastrin is the underlying cause of the diarrhea, proton pumps inhibitors can be used.[1] Below are some of the drugs that can be used in the treatment of chronic diarrhea and some of their mechanisms of actions.
Inhibitors of intestinal transit time
- Opiates
- Loperamide
- Eluxadoline
- Diphenoxylate
- Difenoxin
- Codeine
- Opium
- Paregoric
- Morphine
- Encephalinase inhibitor
- Racecadotril
- 5-HT3-receptor antagonist
- Alosetron
- α2-Adrenergic agonist
- Clonidine
- Somatostatin and analogs
- Octreotide
- Lanreotide
- Pasireotide
- Calcium channel blocker
- Nifedipine
Pro-absorptive agents
- Glucose, amino acids
- Oral rehydration solution
- α2-Adrenergic agonist
- Clonidine
Antisecretory drugs
- Somatostatin and analogs
- Octreotide
- Lanreotide
- Pasireotide
- Enterocyte apical membrane chloride channel inhibitors
- Crofelemer
- Berberine
- Calcium channel blockers
- Nifedipine
- Calmodulin inhibitors
- Chlorpromazine
- Trifluoperazine
- Calcium-sensing receptor ligands
- Calcium
- Nicotinic acid
- Lithium
- Zinc
- Bismuth
- Nonsteroidal antiinflammatory drugs
- Corticosteroids
- Teduglutide
Intraluminal agents
- Adsorbents
- Clays
- Bile acid-binding resins
- Cholestyramine
- Colestipol
- Colesevelam
- Fiber
References
- ↑ 1.0 1.1 Schiller LR (1995). "Review article: anti-diarrhoeal pharmacology and therapeutics". Aliment Pharmacol Ther. 9 (2): 87–106. PMID 7605866.