Diverticulitis pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Cafer Zorkun, M.D., Ph.D. [2]
Overview
Pathophysiology
Pathogenesis
- Pathogenesis of diverticulitis includes three main processes which are change of the intestinal motility, increase of the lumenal pressure, and colonic microenviroment disorder which leads to infection after that.[1]
- In a vivo test of diverticulitis patient colonic tissue with chemicals added, it was overt that there is neuro-alteration to the tissue. It showed increase contractility and loss of relaxation.[2]This alteration in the muscle tissue due to the inflammation which leads to histological changes of the muscle and nerves.
- The mechanism of the inflammation in cases of diverticulitis is known to be caused by histamine, tumor necrosis factor and matrix metalloproteinases. These substances was detected in the colonic tissue biopsies in diverticulitis patients.[3]
- Presence of lymphocytes and granulomas are more predictable of chronic inflammation.
Gross pathology
Histopathological Findings: Actinomycosis diverticulitis & abscess
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References
- ↑ Morris AM, Regenbogen SE, Hardiman KM, Hendren S (2014). "Sigmoid diverticulitis: a systematic review". JAMA. 311 (3): 287–97. doi:10.1001/jama.2013.282025. PMID 24430321.
- ↑ Guagnini F, Valenti M, Mukenge S, Matias I, Bianchetti A, Di Palo S; et al. (2006). "Neural contractions in colonic strips from patients with diverticular disease: role of endocannabinoids and substance P." Gut. 55 (7): 946–53. doi:10.1136/gut.2005.076372. PMC 1856307. PMID 16423891.
- ↑ Tursi A, Elisei W, Brandimarte G, Giorgetti GM, Inchingolo CD, Nenna R; et al. (2012). "Mucosal expression of basic fibroblastic growth factor, Syndecan 1 and tumor necrosis factor-alpha in diverticular disease of the colon: a case-control study". Neurogastroenterol Motil. 24 (9): 836-e396. doi:10.1111/j.1365-2982.2012.01946.x. PMID 22680042.