Heparin-induced thrombocytopenia historical perspective
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Heparin-induced thrombocytopenia |
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Differentiating Heparin-induced thrombocytopenia from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shyam Patel [2]
Overview
Historical Perspective
- In the 1950s, Rodger Weissman and Richard Tobin of Hitchcock Memorial Hospital and Dartmouth Medical School describes the phenomenon of HIT.[1] [2] They noted an alarming increase in the incidence of peripheral arterial embolism after systemic heparin therapy.[1] They reported 10 cases of embolism and thrombotic complications after heparin. [1] Emboli were noted in the femoral, popliteal, and cerebral circulation. This seminal study paved the way for future investigations into the pathophysiology of HIT.
References
- ↑ 1.0 1.1 1.2 WEISMANN RE, TOBIN RW (1958). "Arterial embolism occurring during systemic heparin therapy". AMA Arch Surg. 76 (2): 219–25, discussion 225-7. PMID PMID13497418 Check
|pmid=value (help). - ↑ Lee GM, Arepally GM (2013). "Diagnosis and management of heparin-induced thrombocytopenia". Hematol Oncol Clin North Am. 27 (3): 541–63. doi:10.1016/j.hoc.2013.02.001. PMC 3668315. PMID 23714311.