Lyme disease classification
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Anmol Pitliya, M.B.B.S. M.D.[2]
Overview
Lyme disease may be classified into three stages. The first stage is localized Lyme disease, the second is disseminated Lyme disease and the third is late disseminated Lyme disease. During stage 1, the patient can develop erythema migrans rash. Ten to twenty percent of the patients who have Lyme disease can develop post treatment Lyme disease syndrome.
Classification
Classification based on clinical stage
- Stage 1 is called early localized Lyme disease. The infection is not yet widespread throughout the body.
- Stage 2 is called early disseminated Lyme disease. The bacteria have begun to spread throughout the body.
- Stage 3 is called late disseminated Lyme disease. The bacteria have spread throughout the body.
Classification based on causative organism
- Majority of cases of Lyme disease are caused by Borrelia burgdorferi sensu lato (s.l.) complex. There around 18 genospecies in Borrelia burgdorferi sensu lato (s.l.) complex. Out of these, only 7 infects humans(3 commonly and 4 ocassionally).[1]
| Borrelia burgdorferi sensu lato (s.l.) complex genospecies | ||
|---|---|---|
| Pathogenic | Non- Pathogenic | |
| Commonly infect human | Rarely human infection or not associated with human infection | Not yet isolated from human |
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- However, B. mayonii has recently been discovered to be responsible for development of Lyme disease.[2]
- The following table demonstrates key clinical and epidemiological features that distinguish B. burgdorferi from B. mayonii:
| General information | B. burgdorferi | B. mayonii
|
|---|---|---|
| Transmission | Tick bite | Tick bite |
| Distribution in the USA | Northeast, Mid-Atlantic, and Midwest regions | Midwest region |
| Bacteria Concentration in Blood (Spirochetemia) | Lower | Higher |
| Early Symptoms | Fever, headache, rash, neck pain | Fever, headache, rash, neck pain |
| Late Symptoms and Complications | Joint pain and Arthritis | Joint pain and Arthritis |
| Nausea / Vomiting? | No | Yes |
| Rash Characteristics | Bull's-eye target lesion | Diffuse rash |
| Diagnosis | Serology or PCR | Serology or PCR |
| Treatment | Doxycycline | Doxycycline |
References
- ↑ Rudenko N, Golovchenko M, Grubhoffer L, Oliver JH (2011). "Updates on Borrelia burgdorferi sensu lato complex with respect to public health". Ticks Tick Borne Dis. 2 (3): 123–8. doi:10.1016/j.ttbdis.2011.04.002. PMC 3167092. PMID 21890064.
- ↑ Pritt, Bobbi S; Mead, Paul S; Johnson, Diep K Hoang; Neitzel, David F; Respicio-Kingry, Laurel B; Davis, Jeffrey P; Schiffman, Elizabeth; Sloan, Lynne M; Schriefer, Martin E; Replogle, Adam J; Paskewitz, Susan M; Ray, Julie A; Bjork, Jenna; Steward, Christopher R; Deedon, Alecia; Lee, Xia; Kingry, Luke C; Miller, Tracy K; Feist, Michelle A; Theel, Elitza S; Patel, Robin; Irish, Cole L; Petersen, Jeannine M (2016). "Identification of a novel pathogenic Borrelia species causing Lyme borreliosis with unusually high spirochaetaemia: a descriptive study" (PDF). The Lancet Infectious Diseases. 16 (5): 556–564. doi:10.1016/S1473-3099(15)00464-8. ISSN 1473-3099.