Hypogonadism history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]

Overview

The most common symptoms of hypogonadims in males include delayed puberty and loss of sexual characters as voice deepening and hair growth. Common symptoms include also erectile dysfunction, small testes, loss of libido and sweating. Common symptoms in females include no breast enlargement and no pubic hair. Less common symptoms include headache, visual impairment, galactorrhea and anorexia nervosa.

History and symptoms

History is important in diagnosis of hypogonadism in both males and females. The onset of the symptoms and previous congenital gonadal anomalies should be known.

  • For both males and females:
    • History is important to know if there was any gonadal abnormality since birth or not. The onset of puberty should also be known.
    • Family history of delay of growth and development increases the probability of gonadotropin hormones deficiency and hypogonadism.
  • For males:
    • History of any causes of testicular failure as radiation to testes, chemotherapy or drugs decreasing testosterone secretion.
  • For females:
    • Menstrual history is important and the date of menarche.
    • History of increased androgen secretion as ance and hirsutism.

Common symptoms in males

Symptoms of hypogonadism depends on the onset of the disease whether before puberty or after. In this table, the common symptoms of hypogonadism in both periods are enlisted.[1][2][3]

Pre-pubertal Post-pubertal (Adult)
Delayed puberty and loss of sexual characters:
  • No beard
  • Failure of voice deepening
  • Small or absent testes
  • No muscle mass gaining
  • Micropenis
  • Loss of smelling sense (In cases of Kollmann's syndrome)
  • Decrease of libido
  • Decreased erections
  • Erectile dysfunction
  • Decreased size of testes
  • Sweating
  • Breast enlargement
  • Muscle loss and decreased bone density
  • Infertility
  • Loss of body hair

Common symptoms in female:

  • Delayed puberty and loss of the secondary sexual characteristics:
    • No breast development
    • No pubic hair

Less common symptoms

References

  1. Khera M, Broderick GA, Carson CC, Dobs AS, Faraday MM, Goldstein I; et al. (2016). "Adult-Onset Hypogonadism". Mayo Clin Proc. 91 (7): 908–26. doi:10.1016/j.mayocp.2016.04.022. PMID 27343020.
  2. Basaria S (2014). "Male hypogonadism". Lancet. 383 (9924): 1250–63. doi:10.1016/S0140-6736(13)61126-5. PMID 24119423.
  3. Bhasin S, Cunningham GR, Hayes FJ, Matsumoto AM, Snyder PJ, Swerdloff RS; et al. (2010). "Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline". J Clin Endocrinol Metab. 95 (6): 2536–59. doi:10.1210/jc.2009-2354. PMID 20525905.

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