Psoriasis Screening

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Syed Hassan A. Kazmi BSc, MD [2]

Overview

There is no consensus on screening for psoriasis among the general population but screening methods exist, which can be used to screen for psoriasis. These screening methods include the psoriasis screening tool (PST) and genetic testing.

Screening

Genetic screening for psoriasis

• The strong association of psoriasis with genetics allows screening for this disease via genetic testing.
• HLA Class I antigens (HLA-B13, HLA-B57, HLA-B39, HLA-Cw6, HLACw7) have been known to be associated with psoriasis and psoriatic arthritis.
• HLA-B13, -B16, and its splits -B38 and -B39, B17, and Cw6 are associated with psoriasis, with or without arthritis.
• Early screening combined with early treatment can help prevent disease progression.
• A sample for genetic testing is usually taken from a cheek swab.

Psoriasis screening tool (PST)

• The Psoriasis Screening Tool (PST) consists of eight close ended questions with a "yes" or "no" response with typical images of skin, nail, and scalp changes in psoriasis included with respective questions.
• The questions distinguish individuals with psoriasis from individuals without the disease in an outpatient setting.
• A similar questionnaire exists for psoriatic arthritis, called the Psoriasis Epidemiology Screening Tool (PEST).