Psoriasis Screening
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Psoriasis Screening On the Web |
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American Roentgen Ray Society Images of Psoriasis Screening |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Syed Hassan A. Kazmi BSc, MD [2]
Overview
There are no established guidelines for screening for psoriasis among the general population. Screening methods include the psoriasis screening tool (PST) and genetic testing.
Screening
Genetic screening for psoriasis
- The strong involvement of genetics in the development of psoriasis allows for screening for this disease via genetic testing.
- HLA Class I antigens (HLA-B13, HLA-B57, HLA-B39, HLA-Cw6, HLACw7) have been shown to be associated with psoriasis and psoriatic arthritis.[1]
- HLA-B13, -B16, and its splits -B38 and -B39, B17, and Cw6 are associated with psoriasis, with or without arthritis.
- Early screening combined with early treatment can help prevent disease progression.
- A sample for genetic testing is usually taken from a cheek swab.
Psoriasis screening tool (PST)
- The Psoriasis Screening Tool (PST) consists of eight questions with a "yes" or "no" response with typical images of skin, nail, and scalp changes in psoriasis included with respective questions.[2]
- The questions distinguish individuals with psoriasis from individuals without the disease in an outpatient setting.
- A similar questionnaire exists for psoriatic arthritis, called the Psoriasis Epidemiology Screening Tool (PEST).[3]
References
- ↑ Gladman DD, Farewell VT (2003). "HLA studies in psoriatic arthritis: current situation and future needs". J. Rheumatol. 30 (1): 4–6. PMID 12508382.
- ↑ Dominguez PL, Assarpour A, Kuo H, Holt EW, Tyler S, Qureshi AA (2009). "Development and pilot-testing of a psoriasis screening tool". Br. J. Dermatol. 161 (4): 778–84. doi:10.1111/j.1365-2133.2009.09247.x. PMID 19566664.
- ↑ "Psoriasis Epidemiology Screening Tool (PEST): A Report from the GRAPPA 2009 Annual Meeting | The Journal of Rheumatology".