Addison's disease differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Differentiating Addison's disease from other Diseases

Addison's disease should be differentiated from the following diseases:

• Acanthosis nigricans
• Anorexia nervosa
• Chronic fatigue syndrome
• Depression
• Disorders of oral pigmentation
• Hyperthyroidism
• Laugier-Hunziker Syndrome
• Lentigo
• Malignant melanoma
• Melasma
• Occult malignancy
• Oral manifestations of systemic diseases
• Peutz-Jeghers syndrome
• Type 1 diabetes mellitus
• Vitiligo

Addison's disease (primary adrenal insufficiency) must be first differentiated from secondary and tertiary adrenal insufficiency as all the three of them present with similar symptoms due to cortisol and mineralocorticoid hormone deficiencies. Other conditions that present wi