Hashimoto's thyroiditis causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Furqan M M. M.B.B.S [2]

Overview

Hashimoto's thyroiditis may be caused by T cells and B cells auto activation, genetic factors, and autoimmune antibodies against thyrotropin receptors.

Causes

Hashimoto's thyroiditis usually caused by:^[1]

Common causes

Autoantibodies against Thyroid peroxidase and thyroglobulin.
Abnormalities in the suppressor T cells and regulatory T cells.
HLA-B* 46:01, HLA-A* 02:07 and HLA-DRB4 involvement.

Less common cause

Immunomodulatory drugs (e.g, interferon-alpha.)
Monoclonal antibodies that block CTLA-4
Cancer vaccines
Micro RNA involvement
Polyglandular Syndrome

For the factors involved in the development of Hashimoto's thyroiditis, please click here.

References

↑ Ajjan RA, Weetman AP (2015). "The Pathogenesis of Hashimoto's Thyroiditis: Further Developments in our Understanding". Horm. Metab. Res. 47 (10): 702–10. doi:10.1055/s-0035-1548832. PMID 26361257.

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[pmid26361257-1] Ajjan RA, Weetman AP (2015). "The Pathogenesis of Hashimoto's Thyroiditis: Further Developments in our Understanding". Horm. Metab. Res. 47 (10): 702–10. doi:10.1055/s-0035-1548832. PMID 26361257.

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