Celiac disease diagnostic criteria
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Aditya Ganti M.B.B.S. [2]
Overview
Diagnostic criteria
The diagnosis of celiac disease is made when at least four of the following five or three out of four (if the HLA genotype is not performed) diagnostic criteria are met:[1]
- Typical symptoms (Chronic diarrhea, chronic abdominal pain, malabsorption, bloating, constipation (more commonly in children), failure to thrive/weight loss, anorexia, vomiting, GERD)
- Serum positivity for Ig A autoantibodies at high titer
- HLA-DQ2 or HLA-DQ8 genotypes
- Celiac enteropathy at the small intestinal biopsy
- Response to gluten-free diet
| Symptomatic patients High risk population | |||||||||||||||||||||||||||||||||
| Serology | |||||||||||||||||||||||||||||||||
| Positive | Negative | ||||||||||||||||||||||||||||||||
| Biopsy | Celiac disease is ruled out consider other diagnosis | ||||||||||||||||||||||||||||||||
| Positive | Negative | ||||||||||||||||||||||||||||||||
| Celiac disease | Reevaluate HLA DQ2 and DQ8 other diagnosis | ||||||||||||||||||||||||||||||||
References
- ↑ Rubio-Tapia A, Hill ID, Kelly CP, Calderwood AH, Murray JA (2013). "ACG clinical guidelines: diagnosis and management of celiac disease". Am. J. Gastroenterol. 108: 656–76, quiz 677. doi:10.1038/ajg.2013.79. PMC 3706994. PMID 23609613. Unknown parameter
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