Celiac disease causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Furqan M M. M.B.B.S[2]

Overview

The common causes of celiac disease are autoantibodies to gluten and certain genetic factors.

Causes

Common Causes

Celiac disease is usually caused by:

• Autoantibodies against gluten which is found in:
  • Wheat
  • Barley
  • Rye

Genetic Causes

• Celiac disease is linked to the HLA genes usually HLA DQ2 and HLA DQ8.
  • CELIAC1 (6p21)
• Non-HLA genes are also thought to be related to celiac disease:
  • CELIAC2 (5q31-33)
  • CELIAC3 (2q33)
  • CELIAC4 (19p13·1)