Autoimmune polyendocrine syndrome historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

In 19th century physicians first focussed their attention on constellation of symptoms associated with autoimmune polyendocrine syndrome.
In 1855, Thomas Addison identified patients with Addison's disease who also appeared to have coexisting pernicious anemia.
In 1929, Thorpe and Handley first described the case in a 4.5-year-old girl with mucocutaneous candidiasis with glandular failure.
In 1981, Neufeld and colleagues categorised autoimmune polyendocrine syndrome into type 1 and type 2.