Familial hypocalciuric hypercalcemia laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

Calcium Creatinine Clearance Ratio is used to differentiate FHH from primary hyperparathyroidism, ratio < 0.01 suggestive of FHH and > 0.01 suggestive of primary hyperparathyroidism. Calcium creatinine clearance ratio = [24-hour urine Ca x serum Cr] ÷ [serum Ca x 24-hour urine Cr].

Laboratory Findings

The laboratory findings of FHH are as follows

Laboratory Findings of Familial Hypocalciuric Hypercalcemia
Condition	PTH	Serum Calcium	Serum phosphate	Urine Calcium	Urine Calcium/Serum Creatinine Ratio
Familial Hypocalciuric Hypercalcemia	Normal	Normal or ↑	Normal	↓	↓
Primary Hyperparathyroidism	↑	↑	↓	Normal	↑