Thalassemia historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]
Overview
Historical Perspective
Our knowledge about the origins of thalassemia date back to more than 5000 years ago.
- In 4000 B.C., persons of eastern Mediterranean descent migrated to Sicily, carrying thalassemia gene variants with them.[1]
- In the 800s-900s, there was mass migration of Arabs.
- In the 1400s-1500s, there was further influx of beta-thalassemia mutations with the expansion of the Ottoman Empire.[1] The Ottoman Expire expanded Eastern Europe, Central Asia, and Northern Africa.
- In 1952, Silvestroni and colleagues note that beta-thalassemia trait was highly prevalent in the Po River's delta region.[1]
References
- ↑ 1.0 1.1 1.2 De Sanctis V, Kattamis C, Canatan D, Soliman AT, Elsedfy H, Karimi M; et al. (2017). "β-Thalassemia Distribution in the Old World: an Ancient Disease Seen from a Historical Standpoint". Mediterr J Hematol Infect Dis. 9 (1): e2017018. doi:10.4084/MJHID.2017.018. PMC 5333734. PMID 28293406.