Budd-Chiari syndrome laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

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Laboratory Findings

• When Budd-Chiari syndrome is suspected, measurements are made of :
  • Liver enzyme levels
  • Creatinine
  • Urea
  • Electrolytes
  • LDH
  • Liver biopsy is nonspecific but sometimes necessary to differentiate between Budd-Chiari syndrome and other causes of hepatomegaly and ascites, such as galactosemia or Reye's syndrome
  • Factor V Leiden and Factor II (prothrombin) mutations, for the presence of antiphospholipid antibodies, is usually tested for patients with primary BCS.
  • Bone marrow biopsy can be used to diagnose associated myeloproliferative disorders are common in BCS.
• Laboratory findings consistent with the diagnosis of acute and fulminant BCS include:
  • Elevated Serum aspartate and alanine aminotransferase levels may be more than five times the upper limit of the normal range.
  • Elevated Serum alkaline phosphatase and bilirubin levels, decreased serum albumin level.
• Ascitic fluid examination shows:
  • Total protein level more than 2.5 g per deciliter
  • White blood cells are usually less than 500/μL.
• Additional Hematological tests are recommended to evaluate for hypercoagulability.